Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents

doi:10.1016/J.ARABJC.2011.02.015

Paper

Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents

Published Sep 1, 2016 · Asha B. Thomas, R. Nanda, L. Kothapalli

Arabian Journal of Chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Schiff's bases and 2-azetidinone analogues show potential as antidepressant and nootropic agents, with compounds N ′-[(1 Z)-(2,5-dimethoxyphenyl)methylidene]pyridine-4-carbohydrazide (

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents

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References

Eco-friendly synthesis of 2-azetidinone analogs of isonicotinic acid hydrazide

Novel green methods of sonication and stirring using molecular sieves can achieve higher yields and shorter reaction times for synthesis of 2-azetidinone analogs of isonicotinic acid hydrazide.

Green route synthesis of Schiff's bases of isonicotinic acid hydrazide

Greener methods using sonication, stirring, and microwave irradiation can achieve high yields and shorter reaction times for synthesizing Schiff's bases of isonicotinic acid hydrazide.

Synthesis and biological activity of N-substituted-3-chloro-2-azetidinones.

N-substituted 3-chloro-2-azetidinones exhibit good to moderate antibacterial activity against various microorganisms, but show no antifungal activity against tested fungal species.

Azetidinones as vasopressin V1a antagonists.

Azetidinones show potential as vasopressin V1a antagonists with optimized affinity and pharmacokinetic properties, potentially offering a new treatment option for erectile dysfunction.

Green route for the heterocyclization of 2-mercaptobenzimidazole into beta-lactum segment derivatives containing -CONH- bridge with benzimidazole: Screening in vitro antimicrobial activity with various microorganisms.

The microwave synthesis method provides better yield and shorter time for the efficient synthesis of novel azetidin-2-ones with potential antimicrobial activity.

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