Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase.

doi:10.1016/J.BMC.2006.08.034

Paper

Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase.

Published Dec 15, 2006 · Chuanwen Sun, Xiaodong Zhang, Hai Huang

Bioorganic & medicinal chemistry

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44

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2

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Abstract

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In Vitro Study

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Substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives show potential as potent and selective inhibitors of influenza virus neuraminidase, with 16 and 60 showing the most potential for future development.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase.

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