Paper

Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents.

Published Apr 15, 2012 · Xiaobo Tang, Xiaoke Gu, Zhiguang Ren

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Substituted dibenzo[c,e]azepine-5-ones can reverse multidrug resistance by increasing drug accumulation and inhibiting P-glycoprotein's drug efflux function in drug-resistant cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents.

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