Synthesis and biological evaluation of 3-substituted-benzofuran-2-carboxylic esters as a novel class of ischemic cell death inhibitors.

doi:10.1016/j.bmcl.2010.09.102

Paper

Synthesis and biological evaluation of 3-substituted-benzofuran-2-carboxylic esters as a novel class of ischemic cell death inhibitors.

Published Nov 15, 2010 · J. Suh, K. Yi, Yun S. Lee

Bioorganic & medicinal chemistry letters

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19

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Abstract

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In Vitro Study

Study Snapshot

3-substituted-benzofuran-2-carboxylic esters show promising potential as ischemic cell death inhibitors, with 3-[2-(4-nitro-phenylsulfanyl)-acetylamino]-benzofuran-2-carboxylic acid este

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and biological evaluation of 3-substituted-benzofuran-2-carboxylic esters as a novel class of ischemic cell death inhibitors.

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References

The role of Fas in the progression of ischemic heart failure: prohypertrophy or proapoptosis.

Fas plays a role in both apoptosis and hypertrophy in ischemic heart failure, potentially accelerating the vicious cycle leading to heart failure.

Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity?

FasL-Fas signaling plays a crucial role in various neurological diseases, with non-apoptotic Fas signaling potentially offering neuroplasticity and potential for disease-modifying therapies.

A novel juxtamembrane domain in tumor necrosis factor receptor superfamily molecules activates Rac1 and controls neurite growth.

The novel cytoplasmic membrane proximal domain in Fas proteins activates Rac1 and promotes neurite growth and branching in developing neurons, highlighting its importance in neuronal development.

FasL shedding is reduced by hypothermia in experimental stroke

Mild hypothermia reduces Fas expression and caspase-8 activation in ischemic stroke, while preventing total FasL decreases and increasing membrane-bound FasL.

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Estrogen protects against cerebral ischemia by inhibiting Fas-mediated apoptosis, resulting in smaller infarcts and neuroprotection.

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