Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.

doi:10.1016/j.ejmech.2017.11.016

Paper

Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.

Published Nov 1, 2017 · Yu-Tong Sun, Gui-Fei Wang, Yi-Qiu Yang

European journal of medicinal chemistry

Q2 SJR score

18

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1

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Abstract

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In Vitro Study

Study Snapshot

Newly synthesized 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives show excellent sigma-2 receptor selectivity and moderate anticancer activity against human liver Huh-7 and human esophageal KYSE-140 cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands.

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