Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.

doi:10.1016/j.bmcl.2009.06.018

Paper

Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.

Published Aug 1, 2009 · Q. Yan, R. Cao, Wei Yi

Bioorganic & medicinal chemistry letters

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53

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Abstract

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In Vitro Study

Study Snapshot

5-benzylidene(thio)barbiturate-beta-D-glycosides show potent mushroom tyrosinase inhibitory activities, with compound 12b being the most potent with a IC 50 value of 0.05 mmol/L.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.

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