Synthesis of useful fragments in drug discovery: 2-Amino-5-tert-butylpyridine and its oxidised analogues.

doi:10.1016/j.bmcl.2011.05.066

Paper

Synthesis of useful fragments in drug discovery: 2-Amino-5-tert-butylpyridine and its oxidised analogues.

Published Jul 15, 2011 · C. Thomson, J. Reilly, D. Sandham

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

This novel synthesis of 2-amino-5-tert-butylpyridine improves drug-like properties and yields oxidized fragments, aiding in drug discovery and metabolic clearance processes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of useful fragments in drug discovery: 2-Amino-5-tert-butylpyridine and its oxidised analogues.

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