Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

doi:10.1016/S0968-0896(01)00223-1

Paper

Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

Published Nov 1, 2001 · A. Gangjee, O. Adair, S. Queener

Bioorganic & medicinal chemistry

Q2 SJR score

38

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1

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Abstract

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In Vitro Study

Study Snapshot

The -naphthyl analogue 4 shows the highest selectivity and potency as a dihydrofolate reductase inhibitor against Pneumocystis carinii and Toxoplasma gondii, with potential antimycobacterial activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

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