The synthesis of carbon-14 labelled N,N-diethyl-4-[phenyl-(piperidin-4-ylidene)methyl]-benzamide is described. The radioisotope is introduced via an aryllithium reaction with 14CO2 to form the labelled acid, which is subsequently transformed into the amide. Copyright © 2002 John Wiley & Sons, Ltd.

Carbon-14 labelled N,N-diethyl-4-[phenyl-(piperidin-4-ylidene)methyl]-benzamide, a potent  opioid receptor agonist, can be synthesized using an aryllithium reaction with 14CO2.

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Synthesis of N, N‐diethyl‐4‐[phenyl‐(piperidin‐4‐ylidene)methyl]‐[carboxy‐14C]benzamide, a potent δ opioid receptor agonist

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