Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.

doi:10.1016/j.bmcl.2012.10.025

Paper

Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.

Published Dec 1, 2012 · V. S. Patil, Kamalakar P. Nandre, Sougata Ghosh

Bioorganic & medicinal chemistry letters

Q2 SJR score

19

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1

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Abstract

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In Vitro Study

Study Snapshot

Novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives show significant glycosidase inhibitory activity, potentially benefiting type II diabetes treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.

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