A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.

This mild, photoactivated 1,3-dipolar cycloaddition procedure allows for the efficient synthesis of polysubstituted pyrazolines with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.

Paper

Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition.

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