Synthesis of 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid

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Synthesis of 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid

Published 2007 · Wang Hong-yong

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Abstract

The synthesis of 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid,which is used as the intermediate for iodinated X-ray contrast agents,is described in this paper.5-Amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid was synthesized from monomethyl 5-nitroisophthalate by a three-step procedure,i.e.:amidation,reduction,and iodization.The total yield was 79%.The reduction reaction condition was studied.The optimal reaction conditions were conducted at a ratio of m(Pd)/m(5-nitro-N-(2-hydroxyethyl)-isophthalamic acid)=0.001,a reaction temperature of 75 ℃and a reaction time of 6 h using water as the solvent.The conversion of 5-nitro-N-(2-hydroxyethyl)-isophthalamic acid was 100%.

Study Snapshot

This study presents a three-step procedure for synthesizing 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid, which is used as an intermediate for iodinated X-ray contrast agents, with optimal reaction conditions at 75

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of 5-amino-N-(2-hydroxyethyl)-2,4,6-triiodoisophthalamic acid

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