The reaction of aromatic and heteroaromatic aldehydes with 3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one was studied. A series of new 5-(het)arylidene-3[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-ones was obtained. For synthesized compounds, antitumor and anti-inflammatory activity was studied. Hit-compounds were identified that exceeded the known comparison drugs in their action.

5-(het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one derivatives show promising antitumor and anti-inflammatory activity, surpassing known drugs in their effectiveness.

Russian Journal of General Chemistry

Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

Paper

Synthesis of 5-(Het)arylidene-3-[2-(4-hydroxyphenyl)ethyl]-2-thioxothiazolidine-4-one Derivatives and Study of Their Antitumor and Anti-Inflammatory Activity

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