Paper
Synthesis and Hypolipidemic Activity of Novel 2‐(4‐(2‐Amino‐6‐(4‐Substituted Phenyl) Pyrimidin‐4‐yl)‐2‐Substituted Phenoxy) Acetic Acid Derivatives
Published Apr 1, 2012 · S. Mokale, Maheshwari T. Shete, Sameer I. Shaikh
Chemical Biology & Drug Design
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8
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Abstract
A novel series of 2‐(4‐(2‐amino‐6‐(4‐substituted phenyl) pyrimidin‐4‐yl)‐2‐substituted phenoxy) acetic acid derivatives were efficiently synthesized. The synthesized compounds were evaluated for their in vivo hypolipidemic activity, using high‐fat‐diet‐induced hyperlipidemia in rats. Some of these compounds showed significant antihyperlipidemic activity.
Study Snapshot
Novel 2(4(2amino-6(4substituted phenyl) pyrimidin-4-yl)2substituted phenoxy) acetic acid derivatives show significant antihyperlipidemic activity in rats.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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