The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

Imidazo[1,2-a]pyridines with a thioether side chain show high antiviral activity against human cytomegalovirus and varicella-zoster virus, with a therapeutic index of over 150.

Paper

Synthesis of imidazo[1,2-a]pyridines as antiviral agents.

References

Citations