4-Amino-1,2-dimethylimidazole-5-carbaldehyde (1) and 5-amino-1-methylimidazole-4-carbaldehydes 3 were prepared by reduction of the corresponding aminoimidazolecarbonitriles 2 and 4. Condensation of 1 and 3 with carbonitriles, ketones and polyfunctional carbonyl compounds bearing the-CH2CO-moiety afforded to the imidazo[4,5-b]pyridine derivatives.

This study demonstrates the facile synthesis of imidazo[4,5-b]pyridines from aminoimidazolecarbaldehydes by reducing aminoimidazolecarbonitriles and combining them with carbonitriles, ketones, and polyfunctional carbonyl compounds.

Paper

Synthesis of imidazo[4,5-b]pyridines from aminoimidazolecarbaldehydes

References

Citations