Synthesis of imidazo[4,5-b]pyridines from aminoimidazolecarbaldehydes

doi:10.1002/JHET.5570340118

Paper

DOI: 10.1002/JHET.5570340118

Synthesis of imidazo[4,5-b]pyridines from aminoimidazolecarbaldehydes

Published 1997 · Francisco Perandones, J. Soto

Journal of Heterocyclic Chemistry

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Abstract

4-Amino-1,2-dimethylimidazole-5-carbaldehyde (1) and 5-amino-1-methylimidazole-4-carbaldehydes 3 were prepared by reduction of the corresponding aminoimidazolecarbonitriles 2 and 4. Condensation of 1 and 3 with carbonitriles, ketones and polyfunctional carbonyl compounds bearing the-CH2CO-moiety afforded to the imidazo[4,5-b]pyridine derivatives.

Study Snapshot

This study demonstrates the facile synthesis of imidazo[4,5-b]pyridines from aminoimidazolecarbaldehydes by reducing aminoimidazolecarbonitriles and combining them with carbonitriles, ketones, and polyfunctional carbonyl compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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