Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives.

doi:10.1016/j.bmcl.2011.09.060

Paper

Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives.

Published Nov 15, 2011 · Lili Ding, Ju Zhu, Canhui Zheng

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Substituted 4-amino-N-(diaminomethylene) benzenesulfonamides show potent acrosin inhibitory activities, providing a new scaffold for developing acrosin inhibitory agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives.

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