[Synthesis and positive inotropic action of some 5-substituted 5H-(1)benzopyrano(4,3-b)pyridines].

doi:10.1002/chin.198614210

Paper

[Synthesis and positive inotropic action of some 5-substituted 5H-(1)benzopyrano(4,3-b)pyridines].

Published Apr 8, 1986 · D. Heber, U. Ravens

Arzneimittel-Forschung

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Abstract

The 5-hydroxy-5H-[1]benzopyrano [4,3-b]pyridines (4) were converted to the acetales 7-10 on treatment with alcoholic solutions in the presence of concentrated hydrochloric acid. Reactions of with aliphatic and aromatic amines yielded the aminoacetales 11-15. The effects of compounds 7-15 were examined on the isolated perfused guinea-pig heart.

In Vitro Study

Study Snapshot

The 5-substituted 5H-(1)benzopyrano(4,3-b)pyridines exhibit positive inotropic effects on the isolated perfused guinea-pig heart, suggesting potential as a new class of drugs for heart stimulation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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[Synthesis and positive inotropic action of some 5-substituted 5H-(1)benzopyrano(4,3-b)pyridines].

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