A method has been developed for the synthesis of the angiotensin-converting enzyme inhibitor N-[1-benzyloxycarbonyl-2-(R, S)-ethoxycarbonyl-4-pyrrolidinyl]-alanylproline by the condensation of N-benzyloxy-carbonyl4-ketoproline ethyl ester with alanylproline. The intermediate Schiff's base was reduced with NaB(CN)H3. The yield of the corresponding maleate was 5.4%.

The developed method successfully synthesizes the angiotensin-converting enzyme inhibitor N-[1-benzyloxycarbonyl-2-(R,S)-ethoxycarbonyl-4-pyrrolidinyl]-alanylproline with a yield of 5.4%.

Paper

Synthesis of N-[1-benzyloxycarbonyl-2-(R,S)ethoxycarbonyl-4-pyrrolidinyl]alanylproline

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