Paper

Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.

Published Nov 4, 2002 · H. Ohki, Kenji Hirotani, H. Naito

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

Novel pyrimidinyl pyrazole derivatives show antiproliferative activity against human lung cancer cell lines and inhibit tubulin polymerization, with a different binding pattern than colchicine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.

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