Methyl 2-Amino-377-1 -benzazepine-4-carboxylates or methyl 2-(cyanomethyl)-2,3-dihydro-1 H -indole-2-carboxylates were prepared from the reaction of 3-[2-formamido-, 2-acetamido-, or 2-(propanoylamino)phenyl]-substituted methyl 2-(cyanomethyl)propenoates with sodium methoxide in methanol, respectively. The latter were readily obtained from the Morita-Baylis-Hillman reaction of N-protected 2-aminobenzaldehydes with methyl acrylate followed by acetylation and cyanation.

Methyl 2-(cyanomethyl)-2,3-dihydro-1H-indole-2-carboxylates were prepared by reacting 3-[2-formamido-, 2-acetamido-, or 2-(propanoylamino)phenyl]-

Synthesis

Synthesis of Methyl 2-Amino-3H-1-benzazepine-4-carboxylates and 2-(Cyanomethyl)-2,3-dihydro-1H-indole-2-carboxylates from Morita-Baylis-Hillman Acetates of 2-(Acylamino)benzaldehydes

Paper

Synthesis of Methyl 2-Amino-3H-1-benzazepine-4-carboxylates and 2-(Cyanomethyl)-2,3-dihydro-1H-indole-2-carboxylates from Morita-Baylis-Hillman Acetates of 2-(Acylamino)benzaldehydes

References

Citations