Large-scale synthesis of methyl cis-9, trans-11-octadecadienoate from methyl ricinoleate

doi:10.1007/S11746-997-0018-Z

Paper

Large-scale synthesis of methyl cis-9, trans-11-octadecadienoate from methyl ricinoleate

Published Aug 1, 1997 · Olivier Berdeaux, William W. Christie, F. Gunstone

Journal of the American Oil Chemists' Society

UNKNOWN SJR score

66

Citations

1

Influential Citations

Full textSemantic Scholar

Abstract

The conjugated linoleic acid methyl cis-9,trans-11-octadecadienoate has been prepared on a large scale from methyl ricinoleate. Methyl ricinoleate was purified from castor esters by a partition method. It was converted to the mesylate, which was reacted with a base (1,8-diazabicyclo[5,4,0]-undec-7-ene) to give a product that contained 66% of the desired ester. Two urea crystallizations produced a product containing 83% methyl cis-9,trans-11-octadecadienoate, the identity of which was confirmed by gas chromatography linked to mass spectrometry and by Fourier transform infrared spectroscopy. The remaining impurities were methyl cis-9,cis-11- and cis-9-,trans-12-octadecadienoate.

Study Snapshot

Large-scale synthesis of methyl cis-9,trans-11-octadecadienoate from methyl ricinoleate has been achieved, providing a valuable source for pharmaceutical and biotechnology applications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Large-scale synthesis of methyl cis-9, trans-11-octadecadienoate from methyl ricinoleate

References

Citations