SYNTHESIS OF METHYL ESTERS OF 5-AMINO-4-(SUBSTITUTED AMINO)-2-METHYLTHIO-7H-PYRROLO[2,3- d ]PYRIMIDINE-6-CARBOXYLIC ACIDS

doi:10.1007/265

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SYNTHESIS OF METHYL ESTERS OF 5-AMINO-4-(SUBSTITUTED AMINO)-2-METHYLTHIO-7H-PYRROLO[2,3- d ]PYRIMIDINE-6-CARBOXYLIC ACIDS

Published Feb 6, 2013 · С. Тумкявичюс, А. Урбонас, П. Вайнилавичюс

Chemistry of Heterocyclic Compounds

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Abstract

The optimum route for the synthesis of methyl esters of N-[(4-substituted amino)-5-cyano-2-methylthiopyrimidin-6-yl]amino acids (which are starting materials for preparing the methyl esters of the corresponding 5-amino-4-(substituted amino)pyrrolo[2,3- d ]pyrimidine-6-carboxylic acids) is via subsequent reactions of 4,6-dichloro-2-methylthiopyrimidine-5-carbonitrile with amines and methyl glycinate. In some examples, the reaction of methyl N-(4-chloro-2-methylthio-6-pyrimidinyl)aminoacetate with amines occurs to give the corresponding acid amides. The previously unknown synthesized derivatives of pyrimidin-6-yl amino acids and 4,5-diaminopyrrolo[2,3- d ]pyrimidine-6-carboxylic acids possess fungicidal properties. Authors: S. Tumkevicius, A. Urbonas, and P. Vainilavicius. English Translation in Chemistry of Heterocyclic Compounds , 2000, 36 (7), pp 841-846 http://link.springer.com/article/10.1007/BF02256920

Study Snapshot

The synthesis of methyl esters of 5-amino-4-(substituted amino)-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acids reveals fungicidal properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

SYNTHESIS OF METHYL ESTERS OF 5-AMINO-4-(SUBSTITUTED AMINO)-2-METHYLTHIO-7H-PYRROLO[2,3- d ]PYRIMIDINE-6-CARBOXYLIC ACIDS

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