Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents.

doi:10.1016/j.bioorg.2019.102976

Paper

Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents.

Published Aug 1, 2019 · N. S. El-Gohary, Moustafa T. Gabr, Moustafa T. Gabr

Bioorganic chemistry

Q1 SJR score

35

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1

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Abstract

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In Vitro Study

Study Snapshot

New pyrazolo[3,4-b]pyridine analogs show potential as powerful and extended-spectrum antimicrobial, antiquorum-sensing, and anticancer agents, with 2 and 9c showing the greatest activity against cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, molecular modeling and biological evaluation of new pyrazolo[3,4-b]pyridine analogs as potential antimicrobial, antiquorum-sensing and anticancer agents.

References

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