Synthesis and Molecular Docking Studies of Novel 2-(2-Amino-6-Phenyl-4-Pyrimidinylamino)Ethanol Derivatives: Using Ring-Opening Reactions of Cyclic Ketene-N,O-Acetal.

doi:10.13005/ojc/330361

Paper

Synthesis and Molecular Docking Studies of Novel 2-(2-Amino-6-Phenyl-4-Pyrimidinylamino)Ethanol Derivatives: Using Ring-Opening Reactions of Cyclic Ketene-N,O-Acetal.

Published Jun 20, 2017 · Ravi Kumar G. M. V. N. A. R., A. Thangamani

Oriental journal of chemistry

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Abstract

A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via Oxoketene Dithioacetals with high yields. Ketene dithioacetal store act with 2-aminoethanol or l-amino-2-propanol to afford the corresponding substituted 2-methyleneoxazolidines which are utilized in the synthesis of 6-aryl-2-amino-4-pyrimidinamine Derivatives. The molecular docking studies revealed that all the synthesized compounds best fit into the active site of HDAC2, anti-cancer protein.

Study Snapshot

Novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives synthesized using Oxoketene Dithioacetals show potential as anti-cancer agents by fitting into the active site of HDAC2, an anti-cancer protein.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Synthesis and Molecular Docking Studies of Novel 2-(2-Amino-6-Phenyl-4-Pyrimidinylamino)Ethanol Derivatives: Using Ring-Opening Reactions of Cyclic Ketene-N,O-Acetal.

References

Citations

Divalent cobalt and copper coordination complexes of κ2-N, O-derivatives of (Z)-1-R-2-(2′-oxazolin-2′-yl)-eth-1-en-1-ates: Structure and reactivity patterns

This study synthesised and characterized a small library of Co and Cu derivatives incorporating the (Z)-1-R1-2-(4',4'-R2-2'-oxazolin-2'-yl)-eth-1-en-1-ate skeleton, with some showing stable solid