The key intermediate N,N′-dimethy1-3,3′-dithodipropionamide for preparing isothiazolone was synthesized starting from methyl acrylate by nucleophilic addition,purification with desulfurization and amidating,the total yield reached 85%.The effects of reaction agent relative ratio,reaction temperature and reaction time on the yield were discussed

N,N′-dimethy1-3,3′-dithiodipropionamide synthesized from methyl acrylate shows potential as a key intermediate for preparing isothiazolone, with 85% yield achieved.

Paper

Synthesis of N,N′-Dimethyl-3,3′-dithiodipropionamide

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