Synthesis of Nonsymmetrical5-Aryl-2-indolopyrrole Derivatives via Controlled MonoSuzuki-Miyaura Cross-Coupling on N-Boc-2,5-dibromopyrrole

doi:10.1055/S-0030-1258284

Paper

Synthesis of Nonsymmetrical5-Aryl-2-indolopyrrole Derivatives via Controlled MonoSuzuki-Miyaura Cross-Coupling on N-Boc-2,5-dibromopyrrole

Published Dec 1, 2010 · F. Beaumard, P. Dauban, R. Dodd

Synthesis

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Abstract

The first example of mono Suzuki-Miyaura cross-coupling of N-Boc-2,5-dibromopyrrole with a boronic acid (indol-2-yl-boronic acid) is reported. The resulting 2-indolyl-5-bromopyrrole derivative was in turn coupled with a variety of aryl- or heteroaryl-boronic acids thereby providing the corresponding non-symmetrical 2,5-disubstituted pyrroles in good to excellent yields. The tert-butoxycarbonyl (Boc) groups could be easily removed to give the completely deprotected products.

Study Snapshot

Mono Suzuki-Miyaura cross-coupling on N-Boc-2,5-dibromopyrrole with boronic acid provides nonsymmetrical 2,5-disubstituted pyrroles in good to excellent yields, with easy removal of tert-but

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of Nonsymmetrical5-Aryl-2-indolopyrrole Derivatives via Controlled MonoSuzuki-Miyaura Cross-Coupling on N-Boc-2,5-dibromopyrrole

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