Synthesis of novel α-(N-pentafluorophenylamino) benzylphosphonates and phosphonic acids

doi:10.1080/10426509608046365

Paper

Synthesis of novel α-(N-pentafluorophenylamino) benzylphosphonates and phosphonic acids

Published 1996 · 朱仕正, 许斌, 张杰

Phosphorus Sulfur and Silicon and The Related Elements

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Abstract

Abstract A series of novel α-(N-pentafluorophenylamino)benzyl phosphonic acids are prepared by hydrolysis of corresponding phosphonates, C6F5NHCH(Ar)P(O)(OR)2 which are synthesized from the addition of N-pentafluorophenyl aromatic aldimines with dialkyl phosphite. The X-ray diffraction of C6F5NHCH(4-CH3C6H4)P(O)(OCH3), is presented.

Study Snapshot

This study demonstrates the successful synthesis of novel -(N-pentafluorophenylamino)benzyl phosphonic acids by hydrolysis of corresponding phosphonates, with promising applications in organic synthesis and catalysis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of novel α-(N-pentafluorophenylamino) benzylphosphonates and phosphonic acids

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References

Synthesis of perfluoroalkanesulfonylaminoalkylphosphonic acids

Perfluoroalkanesulfonylaminoalkylphosphonic acids were successfully synthesized in high yield by hydrolyzing perfluoroalkanesulfonylaminoalkylphosphites, with the molecular structure presented.

Synthesis of N-pentafluorophenyl aromatic aldimines C6F5N=CHAr and an X-ray structure analysis of N-pentafluorophenyl-4-methylphenyl aldimine, C6F5N=CHC6H4CH3-4

N-pentafluorophenyl aromatic aldimines were successfully synthesized and characterized by X-ray structure analysis.

Synthesis and Antitumor Activity of Novel a-Substituted Aminomethylphosphonates

Novel -substituted aminomethyl phosphonates show potential antitumor activity, inhibiting leukemia L1210 cell growth in vitro.

Synthesis of N-perfluoroalkanesulfonyl aromatic imines

N-perfluoroalkanesulfonyl aromatic imines can be synthesized by refluxing perfluoroalkanesulfonamides with thionyl chloride, resulting in R f SO 2 NCHAr through elimination of sulfurdioxide.

OPTICALLY ACTIVE 1-AMINOALKYLPHOSPHONIC ACIDS

1-Aminoalkylphosphonic acids 1 exhibit diverse biological activities, including antibacterial, analgesic, and antifungal properties, depending on their absolute configuration.

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