Synthesis of Novel 3-(Pyridin-4-yl)-1,2,4-Triazines, their Analogs and Study of the Activity Against Vaccinia Virus

doi:10.1007/s10593-021-02924-4

Paper

Synthesis of Novel 3-(Pyridin-4-yl)-1,2,4-Triazines, their Analogs and Study of the Activity Against Vaccinia Virus

Published Apr 1, 2021 · O. Shabunina, Y. Shtaitz, D. Kopchuk

Chemistry of Heterocyclic Compounds

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5

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Abstract

Using atom-economical approaches, new representatives of 3-(pyridin-4-yl)-1,2,4-triazines and their 4-nitrophenyl analogs were obtained, and their activity in relation to the vaccinia virus was studied. The new compounds have shown promising characteristics, in particular, in comparison to the antiviral drug Cidofovir.

Study Snapshot

Novel 3-(pyridin-4-yl)-1,2,4-triazines show promising activity against vaccinia virus, particularly compared to the antiviral drug Cidofovir.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of Novel 3-(Pyridin-4-yl)-1,2,4-Triazines, their Analogs and Study of the Activity Against Vaccinia Virus

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References

Citations

TRANSFORMATIONS OF 5-HYDRAZINYL-1,2,4-TRIAZINES IN THE REACTION WITH 2,5-NORBORNADIENE

At elevated temperature and pressure, 5-hydrazinyl-1,2,4-triazines and 2,5-norbornadiene react to produce 2-aminopyridines, 5-amino-1,2,4-triazines, and 6-unsubstituted pyridines, depending

Functionalized Triazines and Tetrazines: Synthesis and Applications

Recent developments in synthesis and applications of triazines and tetrazines offer new possibilities for chemical biology investigations.

Synthesis of 3,5-difuroxanyl-1,6-dihydro-1,2,4-triazines

The study proposes a mild method for synthesizing 3,5-difuroxanyl-1,6-dihydro-1,2,4-triazines by reacting (furoxanyl)amdrazones with 4-amino-3-bromoacetylfuroxan