In a search for substances that might be useful hypocholesteremic agents, a series of twenty five N-substituted maleamic acids was prepared. These compounds were produced in satisfactory yields by the aminolysis of maleic anhydride with appropriate aliphatic, aromatic and heterocyclic amines in various solvents under similar conditions. Analytical data as well as spectroscopic characterizations are provided.

N-substituted maleamic acids show potential as useful hypocholesteremic agents by producing satisfactory yields through aminolysis of maleic anhydride with appropriate amines in various solvents under similar conditions.

Paper

Synthesis Of N-Substituted Maleamic Acids as Potential Hypocholesteremics†

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