Synthesis of pharmacologically active 1-amino-isoquinolines prepared via silver triflate-catalyzed cyclization of o-alkynylbenzaldoximes with isocyanates.

doi:10.1016/j.ejps.2013.09.021

Paper

Synthesis of pharmacologically active 1-amino-isoquinolines prepared via silver triflate-catalyzed cyclization of o-alkynylbenzaldoximes with isocyanates.

Published Jan 23, 2014 · A. Mantovani, A. Pesarico, T. B. Sampaio

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

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19

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1

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Abstract

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In Vitro Study

Study Snapshot

1-amino-isoquinolines synthesized via silver triflate-catalyzed cyclization show antioxidant properties and antidepressant-like effects in mice without causing acute toxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of pharmacologically active 1-amino-isoquinolines prepared via silver triflate-catalyzed cyclization of o-alkynylbenzaldoximes with isocyanates.

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