A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.

This one-pot synthesis of polysubstituted pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions demonstrates a facile and efficient mechanism for synthesis of complex organic compounds.

Paper

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.

References

Citations