A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.

doi:10.1021/OL702846T

Paper

A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.

Published Jan 17, 2008 · Dexuan Xiang, Kewei Wang, Yongjiu Liang

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Abstract

A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from a variety of beta-oxo amides under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation and intramolecular nucleophilic cyclization is proposed.

Study Snapshot

This one-pot synthesis of polysubstituted pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions demonstrates a facile and efficient mechanism for synthesis of complex organic compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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A facile and efficient synthesis of polyfunctionalized pyridin-2(1H)-ones from beta-oxo amides under Vilsmeier conditions.

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