Stereoselective synthesis of polyhydroxylated pyrrolidines: a route to novel 3,5-bis(hydroxymethyl)pyrrolidines from 2-azabicyclo[2.2.1]hept-5-enes

doi:10.1016/J.TETLET.2006.08.077

Paper

Stereoselective synthesis of polyhydroxylated pyrrolidines: a route to novel 3,5-bis(hydroxymethyl)pyrrolidines from 2-azabicyclo[2.2.1]hept-5-enes

Published Oct 23, 2006 · M. Alves, X. García‐Mera, M. L. Vale

Tetrahedron Letters

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Abstract

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Study Snapshot

This study presents a efficient method for preparing racemic and chiral 3,5-bis(hydroxymethyl)pyrrolidines from 2-azabicyclo[2.2.1]hept-5-enes, enabling the synthesis of novel compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Stereoselective synthesis of polyhydroxylated pyrrolidines: a route to novel 3,5-bis(hydroxymethyl)pyrrolidines from 2-azabicyclo[2.2.1]hept-5-enes

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References

Experimental and DFT study of the aza-Diels-Alder reaction between cyclopentadiene and protonated benzylimine derivated from glyoxylates

The aza-Diels-Alder reaction between cyclopentadiene and protonated benzylimine from glyoxylates exhibits exo stereoselectivity, with solvent effects enhancing this effect, and this effect increases with solvent polarity.

Efficient Synthesis of Structurally Diverse Diazabicycloalkanes: Scaffolds for Modular Dipeptide Mimetics with Tunable Backbone Conformations

This study presents a stereoselective synthesis of diverse dipeptide mimetics using a diazabicycloalkane scaffold, enabling the creation of modular ligands and solid-phase-attached scaffolds in combinatorial chemistry.

The total synthesis of (--)-lemonomycin.

The total synthesis of (-)-lemonomycin, a novel antitumor antibiotic, has been achieved using a highly convergent synthetic strategy, enabling its potential use in cancer therapy.

A highly stereoselective approach to novel 2,2,4-trisubstituted pyrrolidines by halocylization: key intermediates towards syntheses of nitrogen analogs of Noxafil®

This study presents a highly stereoselective approach to synthesize novel 2,2,4-trisubstituted pyrrolidines, which could serve as intermediates for synthesizing nitrogen analogs of Noxafil®.

New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.

Carbocyclic nucleosides show promising potential for pharmacological applications due to their optical purity and ability to recognize enzymes of pharmacological importance.

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