Synthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)pyrimidin-7(6H)-one-2(3H)-thiones.

doi:10.1002/CHIN.197751264

Paper

Synthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)pyrimidin-7(6H)-one-2(3H)-thiones.

Published Dec 20, 1977 · M. B. Devani, C. Shishoo, U. S. Pathak

Arzneimittel-Forschung

UNKNOWN SJR score

6

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

4-Amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)-pyrimidin-7(6H)-one-2(3H)-thiones have been synthesized and screened for antimicrobial and pharmacological activities. Significant analgesic, antiinflammatory, anticonvulsant and antimicrobial properties have been found in some of the compounds synthesized. Analgesic and antiinflammatory activities are reported for the first time in thiazole-2(3H)-thiones.

Study Snapshot

4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)-pyrimidin-7(6H)-one-2(3H)-thiones show significant analgesic, antiinflammatory, anticonvulsant

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)pyrimidin-7(6H)-one-2(3H)-thiones.

Sign up to use Study Snapshot

References

Citations

A consensus reverse docking approach for identification of a competitive inhibitor of acetyltransferase enhanced intracellular survival protein from Mycobacterium tuberculosis.

LQM495 shows promise as a competitive inhibitor of Mycobacterium tuberculosis' enhanced intracellular survival protein, which could be explored for developing novel anti-TB drugs in the future.

Synthesis, Structural Characterization and Anticancer Activity of New 5-Trifluoromethyl-2-thioxo-thiazolo[4,5-d]pyrimidine Derivatives

New 5-trifluoromethyl-2-thioxo-thiazolo[4,5-d]pyrimidine derivatives show potential anticancer activity, with 7-Chloro-3-phenyl-5-(trifluoromethyl)[1,3]thiazolo[4,5-d]pyrim

Utility of Activated Nitriles in the Synthesis of Some New Heterocyclic Compounds

Activated nitriles can be used as key intermediates for the synthesis of new heterocyclic compounds, such as thiazole, pyrazole, oxazole, pyrimidine, 1,3-dithiolane, thiophene, coumarin, o

Synthesis and Antimicrobial Evaluation of Some New Thiophene Derivatives

New thiophene derivatives, such as 12b, show high antimicrobial activity against Ampicillin, making them potential candidates for antimicrobial drug discovery.

Synthesis and Antitumor Screening of Novel 3-Phenylthiazolo [4,5-d]pyrimidin-2-thione Derivatives

Novel 3-phenylthiazolo [4,5-d]pyrimidine-2-thione derivatives show promising antitumor activity against 60 human tumor cell lines.