The synthesis, physicochemical properties and immunological activity of 5-amino-3-methylisoxazolo[5,4-d]4-pyrimidinone derivatives.

Paper

The synthesis, physicochemical properties and immunological activity of 5-amino-3-methylisoxazolo[5,4-d]4-pyrimidinone derivatives.

Published 2005 · M. Mączyński, M. Zimecki, Ewa Drozd-Szczygieł

Cellular & molecular biology letters

Q1 SJR score

15

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0

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Semantic Scholar

Abstract

A series of 5-amino-3-methylisoxazole[5,4-d]4-pyrimidinone derivatives were obtained by reacting substituted 5-amino-3-methylisoxazol-4-carboxylic acid hydrazide with ethyl ortho-formate. The compounds were tested using the models of in vivo cellular and humoral immune response in mice and pokeweed mitogen-induced (PWM-induced) polyclonal antibody production in a culture of human peripheral blood mononuclear cells (PBMC). The compounds exhibited differential inhibitory activities in the described models, depending on the character and location of the substituted groups. We suggest that the compounds affect the early stages of the immune response.

In Vitro Study

Study Snapshot

Different 5-amino-3-methylisoxazole[5,4-d]4-pyrimidinone derivatives show differential inhibitory activities in early stages of immune response, suggesting they affect early stages of immune response.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

The synthesis, physicochemical properties and immunological activity of 5-amino-3-methylisoxazolo[5,4-d]4-pyrimidinone derivatives.

References

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Citations

Synthesis, Physicochemical Characteristics and Plausible Mechanism of Action of an Immunosuppressive Isoxazolo[5,4-e]-1,2,4-Triazepine Derivative (RM33)

RM33 is an efficient, nontoxic immune suppressor with prevailing anti-inflammatory action, exhibiting no cell toxicity and no apoptosis in cells.

Isoxazole Derivatives as Regulators of Immune Functions

Isoxazole derivatives show promising immunoregulatory properties, with low toxicity and good bioactivity at low doses, potentially benefiting chemotherapy patients.

Infrared spectra and other properties predictions of 5-amino-3-methyl-4-isoxazolecarbohydrazide with electric field simulation using CPC model

The CPCM model effectively simulates infrared spectra and structural parameters of 5-amino-3-methyl-4-isoxazolecarbohydrazide, providing more reliable results than the Periodic Boundary Conditions method.

5‐Amino‐3‐methyl‐4‐isoxazolecarboxylic acid hydrazide derivatives with in vitro immunomodulatory activities

5amino-3methyl-4isoxazolecarboxylic acid hydrazide derivatives show immunomodulatory effects, with hydrazide showing the most robust effect and IL-1 production being more profoundly regulated than TNF-.

Anti-inflammatory properties of an isoxazole derivative — MZO-2

MZO-2, when applied systemically or locally, shows potential as a drug for alleviating inflammatory processes.