Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

doi:10.1016/j.bmc.2009.12.046

Paper

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

Published Feb 1, 2010 · Takaaki Kobayashi, Mizuki Watanabe, A. Yoshida

Bioorganic & medicinal chemistry

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6

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1

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Abstract

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In Vitro Study

Study Snapshot

Cyclopropane-based conformationally restricted analogs of 4-methylhistamine show strong affinity for histamine H3 receptors, with more potent antagonistic effects than thioperamide.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

References

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