Synthesis, molecular properties prediction and cytotoxic screening of 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones.

doi:10.1016/j.bmcl.2016.04.065

Paper

Synthesis, molecular properties prediction and cytotoxic screening of 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones.

Published Jun 15, 2016 · Angélica Faleiros da Silva Maia, R. Siqueira, F. M. de Oliveira

Bioorganic & medicinal chemistry letters

Q2 SJR score

15

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Abstract

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In Vitro Study

Study Snapshot

The synthesized 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones show selective cytotoxic effect on leukemia cancer cells, with compound 18 triggering apoptosis on NALM6 cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, molecular properties prediction and cytotoxic screening of 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones.

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