Synthesis and pharmacological properties of new pyridine derivatives.2,6-bis-[diphenyl-(and dibenzyl)-hydroxymethyl]-piperidines.

Paper

Synthesis and pharmacological properties of new pyridine derivatives.2,6-bis-[diphenyl-(and dibenzyl)-hydroxymethyl]-piperidines.

Published 1975 · L. Kuczyński, M. Wilimowski, M. Bagińska

Polish journal of pharmacology and pharmacy

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Abstract

Syntheses of 2,6-bis-(diphenylhydroxymethyl)-, 2,6-bis-(dibenzylhydroxymethyl)- and 2,6-bis-(phenylbenzylhydroxymethyl)-pyridines were carried out. These compound were hydrogenated to the corresponding piperidine carbinols. The compounds are of low toxicity and were tested on mice for their CNS activity, using climbing test. 2,6-bis-(dibenzylhydroxymethyl)-piperidine (VI) exhibited central depressive activity.

Non-RCT

Animal Study

Study Snapshot

2,6-bis-(dibenzylhydroxymethyl)-piperidine (VI) shows central depressive activity in mice, with low toxicity and potential for further development as antidepressants.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and pharmacological properties of new pyridine derivatives.2,6-bis-[diphenyl-(and dibenzyl)-hydroxymethyl]-piperidines.

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