Chemoenzymatic synthesis of (3 S,4 S)- and (3 R,4 R)-3-methoxy-4-methylaminopyrrolidine

doi:10.1016/J.TETLET.2004.08.167

Paper

DOI: 10.1016/J.TETLET.2004.08.167

Chemoenzymatic synthesis of (3 S,4 S)- and (3 R,4 R)-3-methoxy-4-methylaminopyrrolidine

Published Oct 18, 2004 · A. Kamal, Ahmad Ali Shaik, Mahendra Sandbhor

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Study Snapshot

Chemoenzymatic enantioselective synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, a key intermediate for the new quinolone antitumor compound AG-7352, is a feasible method for preparing key intermediates

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1016/J.TETASY.2004.01.033

Synthesis of enantiopure β-azidoalcohols from their ketoazides by reduction with NaBH4 in the presence of alumina and in situ lipase resolution

This study presents a novel method for enantioselective synthesis of chiral -azidoalcohols using NaBH4 in the presence of moist aluminium oxide and in situ lipase resolution, offering excellent results under mild reaction conditions.

2004·26citations·A. Kamal et al.·Tetrahedron-asymmetry

Tetrahedron-asymmetry

DOI: 10.1021/JM0304966

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.

The 6-unsubstituted 1,8-naphthyridine structure has the most potent cytotoxic activity against murine P388 leukemia, while 5-chloro and 5-trifluoromethyl groups decrease the cytotoxic activity by 5- to 10-fold.

2004·78citations·Y. Tsuzuki et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/S0040-4039(03)01362-5

A short, simple and general approach for the synthesis of (3S,4S)-3-methoxy-4-methylamino pyrrolidine and (3S,4R)-3-methoxy-4-methylamino pyrrolidine

This study presents a general and efficient stereoselective approach for the synthesis of (3S,4S)-3-methoxy-4-methylamino pyrrolidine, a component of AG-7352, a naphthyridine antitumor agent and quinoline antibacterial compound

2003·12citations·Aran Kumar et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1016/S0040-4039(03)00945-6

Chemoenzymatic synthesis of duloxetine and its enantiomer: lipase-catalyzed resolution of 3-hydroxy-3-(2-thienyl) propanenitrile

Lipase-mediated resolution of 3-hydroxy-3-(2-thienyl) propanenitrile enables efficient and facile chemoenzymatic synthesis of duloxetine and its enantiomer.

2003·52citations·A. Kamal et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1016/S0960-894X(02)00256-1

Efficient chemoenzymatic synthesis of (S)- and (R)-5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide: key intermediate for Src-SH2 inhibitor.

This study demonstrates a facile chemoenzymatic synthesis of both the S and R forms of 5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide, a key intermediate for non-peptidic Src SH2 inhibitors, in high

2002·9citations·A. Kamal et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

Citations

DOI: 10.1039/C8NJ00485D

Biocatalytic approaches towards the stereoselective synthesis of vicinal amino alcohols

Recent advances in biocatalysis, fueled by protein engineering or screening, have greatly improved the number of synthetic opportunities for chiral 1,2-amino alcohols, potentially benefiting pharmaceutical research and biotechnology.

2018·35citations·Pankaj Gupta et al.·New Journal of Chemistry

New Journal of Chemistry

DOI: 10.1016/J.CCR.2017.08.008

Lipases in asymmetric transformations: Recent advances in classical kinetic resolution and lipase–metal combinations for dynamic processes

Lipases and metal catalysts can efficiently produce enantiomerically pure chiral intermediates like alcohols and amines, benefiting various industries.

2017·62citations·Z. Seddigi et al.·Coordination Chemistry Reviews

Coordination Chemistry Reviews

DOI: 10.1002/0471264180.OR089.01

Olefin Ring‐Closing Metathesis

The olefin ring-closing metathesis reaction catalyzed by ruthenium and molybdenum complexes has revolutionized the synthesis of natural products and drug discovery targets.

2016·3citations·L. Yet·Organic Reactions

Organic Reactions

DOI: 10.1016/j.bmc.2014.05.014

Enzymatic preparation of cis and trans-3-amino-4-hydroxytetrahydrofurans and cis-3-amino-4-hydroxypyrrolidines.

Lipase-catalyzed resolution of cis and trans-3-amino-4-hydroxytetrahydrofurans and cis-3-amino-4-hydroxypyrrolidines yields the best enantioselectivity, with Candida antarctica lipases

2014·4citations·Ángela Villar-Barro et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.1016/J.TET.2013.04.112

Chemoenzymatic synthesis of orthogonally protected (3R,4R)- and (3S,4S)-trans-3-amino-4-hydroxypyrrolidines

Orthogonally protected racemic trans-3-amino-4-hydroxypyrrolidines can be easily prepared from N-Cbz-3,4-epoxypyrrolidine using lipase-catalyzed aminolysis, transesterification, or hydrolysis reactions.

2013·8citations·J. A. Rodríguez-Rodríguez et al.·Tetrahedron

Tetrahedron