Synthesis and Reactions of 11-Substituted 3,3-Dimethyl-2,3,4,5-tetrahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones.

doi:10.1002/CHIN.198612278

Paper

Synthesis and Reactions of 11-Substituted 3,3-Dimethyl-2,3,4,5-tetrahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones.

Published Mar 25, 1986 · K. Matsuo, Mitsuhiro Yoshida, M. Ohta

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Abstract

11-Substituted 3, 3-dimethyl-2, 3, 4, 5-tetrahydro-1H-dibenzo [b, e] [1, 4] diazepin-1-ones were synthesized by dehydrative cyclization of 3-(2-acylaminoanilino)-5, 5-dimethyl-2-cyclohexen-1-ones with polyphosphoric acid. The 11-phenyl derivative showed moderate analgesic activity.

Study Snapshot

The 11-phenyl derivative of 3,3-dimethyl-2,3,4,5-tetrahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones showed moderate analgesic activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Synthesis and Reactions of 11-Substituted 3,3-Dimethyl-2,3,4,5-tetrahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones.

References

Synthesis and Reactions of 11-Substituted 3,3-Dimethyl-2,3,4,5-tetrahydro-1H-dibenzo [b, e] [1,4] diazepin-1-ones

The 11-phenyl derivative of 3,3-dimethyl-2,3,4,5-tetrahydro-1H-dibenzo [b, e] [1,4] diazepin-1-ones showed moderate analgesic activity.

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