Diethyl ethoxymethyleneoxalacetate and acetamidine gave 2-methyl-4,5-bis(carbethoxy)-pyrimidine. The ester was converted to 2-methyl-4, 5-pyrimidinedicarbonitrile which gave 2-methyl-4-methoxy-5-pyrimidinecarbonitrile when treated with methanol at room temperature. Attempts to hydrogenate the dinitrile in the presence of nucleophiles led to displacement at C-4. Attempted hydrogenation of the dinitrile in dimethylformamide gave 2,2′-dimethyl-5, 5′-dicyano-4, 4′-bipyrimidine.

The synthesis of 2-methyl-4,5-pyrimidinediearbonitrile using diethyl ethoxymethyleneoxalacetate and acetamidine yields 2-methyl-4-methoxy-5-pyrimidinecarbonitrile, which can be converted to 2-methyl-4,5-pyr

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The synthesis and some reactions of 2‐methyl‐4,5‐pyrimidinediearbonitrile

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