4-(4-Bromo-2-fluoranilino)-7-hydroxy-6-methoxyquinazoline is a key intermediate for vandetanib,which is an antagonist of the vascular endothelial growth factor receptor(VEGFR)and the epidermal growth factor receptor(EGFR).The title compound was obtained from 4-hydroxy-3-methoxybenzoic acid in several steps in an overall yield of 42.6%.

4-(4-Bromo-2-fluoranilino)-7-hydroxy-6-methoxyquinazoline is a key intermediate for vandetanib, an anti-VEGFR and epidermal growth factor receptor (EGFR) inhibitor.

Paper

Synthesis of 4-(4-Bromo-2-fluoranilino)-7-hydroxy-6-methoxyquinazoline

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