An efficient asymmetric synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid, the acid segment of oxybutynin

doi:10.1016/J.TETLET.2006.07.101

Paper

An efficient asymmetric synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid, the acid segment of oxybutynin

Published Sep 25, 2006 · Siddhartha Roy, Anubha Sharma, N. Chattopadhyay

Tetrahedron Letters

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15

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0

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Abstract

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Study Snapshot

This study developed an efficient, inexpensive, and simple asymmetric synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid, the acid segment of oxybutynin, using a chiral template-driven Grignard addition with absolute diastereocontrol.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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An efficient asymmetric synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid, the acid segment of oxybutynin

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