Paper
Synthesis of 2-(4-arylthiosemicarbazidocarbonylthio)benzthiazoles and their monoamine oxidase inhibitory and anticonvulsant properties.
Published Jul 1, 1975 · S. Singh, R. S. Misra, S. Parmar
Journal of pharmaceutical sciences
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Abstract
Ten 2-(4-arylthiosemicarbazidocarbonylthio)benzthiazoles were synthesized, characterized, and evaluated for their monoamine oxidase inhibitory and anticonvulsant activities. All substituted benzthiazoles inhibited activity of monoamine oxidase in rat brain homogenate where the degree of enzyme inhibition was higher with kynuramine as compared to tyramine and 5-hydroxytryptamine as the substrates. All substituted benzthiazoles possessed measurable anticonvulsant activity against pentylenetetrazol-induced convulsions.
In Vitro Study2-(4-arylthiosemicarbazidocarbonylthio)benzthiazoles show both monoamine oxidase inhibitory and anticonvulsant properties, with kynuramine showing the highest inhibition.
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