Paper
SYNTHESIS OF SOME 6-BROMO QUINAZOLINONE DERIVATIVES FOR THEIR PHARAMCOLOGICAL ACTIVITIES.
Published 2010 · Ch. Rajveer, D. Kumaraswamy, S. Sudharshini
International journal of pharma and bio sciences
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Abstract
A number of substituted 6-bromoquinazolinones are known for their pharmacological importance like anti-inflammatory, analgesic and anti-bacterial act ivity. In the present investigation is carried out for the synthesis of 2-(6-bromo-2-phenyl-4-oxoquinazol in-3(4H)-yl)-N-substituted acetamides and 1-Amino-5-(6- bromo-3, 4-dihydro-2-phenyl-4-oxoquinazolin-3yl) methyl-1, 3, 4-triazin-2-thiol to carry out their pharmacological activities. A number of oxoquinazoline derivatives have been synthesized, purified and characterized with the help of their analytical and spectral data (IR, NMR & Mass).The required ethyl (6-bromo- 2-phenyl-4-oxoquinazolin-3(4H)-yl) acetate has been synthesized from 6-bromo-2-phenyl-1,3,4-benzoxazinone and ethyl glycinate. By the use of corresponding p rimary amines the N-substituted acetamides and by t he use of hydrazine hydrate the 1-amino-5-(6-bromo-2-phenyl-4-oxoquinazolin-3(4H)-yl) methyl 1, 3, 4-triazin-2-t hiol were prepared. The synthesized compounds were screened for their anti-bacterial activity, anti-inflamm atory activity and analgesic activity by standard methods . The compound shows Pharmacological activities in comparison with the standard.
The synthesized 6-bromoquinazolinone derivatives show promising pharmacological activities, including anti-bacterial, anti-inflammatory, and analgesic properties.
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