Synthesis, spectroscopic characterization and in vitro antimicrobial, anticancer and antileishmanial activities as well interaction with Salmon sperm DNA of newly synthesized carboxylic acid derivative, 4-(4-methoxy-2-nitrophenylamino)-4-oxobutanoic acid.

doi:10.1016/j.saa.2014.11.061

Paper

Synthesis, spectroscopic characterization and in vitro antimicrobial, anticancer and antileishmanial activities as well interaction with Salmon sperm DNA of newly synthesized carboxylic acid derivative, 4-(4-methoxy-2-nitrophenylamino)-4-oxobutanoic acid.

Published Mar 5, 2015 · M. Sirajuddin, Saqib Ali, V. McKee

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

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Abstract

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In Vitro Study

Study Snapshot

The novel carboxylic acid derivative, 4-(4-methoxy-2-nitrophenylamino)-4-oxobutanoic acid, shows significant anticancer activity and shows potential in pharmaceutics for treating various diseases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, spectroscopic characterization and in vitro antimicrobial, anticancer and antileishmanial activities as well interaction with Salmon sperm DNA of newly synthesized carboxylic acid derivative, 4-(4-methoxy-2-nitrophenylamino)-4-oxobutanoic acid.

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References

Citations

Synthesis, characterization, exploration of anti-cancer, anti-leishmanial, anti-microbial activities, pharmacokinetic and docking studies of Sn(IV) complexes

Sn(IV) complexes show good anticancer potential and exhibit good anti-leishmanial activity, suggesting potential for cancer treatment and antimicrobial applications.

Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Isoindole-1,3-(2H) dione derivatives show promising antimicrobial, antioxidant, antileishmanial, and anticancer activities, with compound 3 being the most effective against Leishmania tropica and exhibiting antiproliferative activity against human cancer cell lines.

Study of the binding interaction of salmon sperm DNA with nintedanib, a tyrosine kinase inhibitor using multi-spectroscopic, thermodynamic, and in silico approaches

Nintedanib has a moderate binding affinity with salmon sperm DNA, with its binding mode being minor groove, contributing to its molecular mechanisms and pharmacological effects.

Antimicrobial Activities of a Novel Marine Streptomyces sp. MMM2 Isolated from El- Arish coast, Egypt

Streptomyces sp. MMM2, a novel marine strain from El- Arish coast, Egypt, produces effective antimicrobial compounds against various bacteria and fungi, with potential applications in pharmaceuticals and cosmetics.

Antileishmanial activity of Riparin structural analogs of Aniba riparia: Biological evaluation, in silico Adme-Tox, and molecular docking.

Riparins, especially RipC and RipE, show cytotoxic activity against Leishmania major promastigotes and high selectivity index, suggesting potential for antileishmanial therapy.