Synthesis, stereochemistry, and antimicrobial evaluation of substituted piperidin-4-one oxime ethers.

doi:10.1016/J.EJMECH.2006.02.005

Paper

Synthesis, stereochemistry, and antimicrobial evaluation of substituted piperidin-4-one oxime ethers.

Published Jun 1, 2006 · C. Ramalingan, Y. T. Park, S. Kabilan

European journal of medicinal chemistry

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62

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Abstract

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In Vitro Study

Study Snapshot

Substituted piperidin-4-one oxime ethers show promising antibacterial and antifungal properties, with potential for development of novel drugs with better pharmacological profiles than standard drugs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, stereochemistry, and antimicrobial evaluation of substituted piperidin-4-one oxime ethers.

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References

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2,6-diaryl-3-methyl-4-piperidone derivatives show potential as analgesic, local anaesthetic, and antifungal agents, with 2-(4-Methylphenyl)-3-methyl-6-(4-chlorophenyl)-piperidin

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Antifungal agents have three main classes, and their resistance mechanisms are similar to those of antibacterials, with a correlation between the two.

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Current and emerging azole antifungal agents offer effective treatment for various fungal infections, but resistance to these drugs is emerging, requiring combination with other agents for enhanced efficacy.

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The chemistry of benzotriazole. A novel and versatile synthesis of 1-alkyl-, 1-aryl-, 1-(alkylamino)-, or 1-amido-substituted and of 1,2,6-trisubstituted piperidines from glutaraldehyde and primary amines or monosubstituted hydrazines

This study presents a novel and versatile synthesis of 1,2,6-trisubstituted piperidines from glutaraldehyde and primary amines or monosubstituted hydrazines, providing a versatile tool for the synthesis of various N-substituted piperid

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