Synthesis and Structural Studies of (2-Oxo-2,3-dihydroimidazo[1,2-a]-pyridin-3-yl)acetic Acids

doi:10.3987/COM-03-9909

Paper

Synthesis and Structural Studies of (2-Oxo-2,3-dihydroimidazo[1,2-a]-pyridin-3-yl)acetic Acids

Published 2004 · W. Chui, A. Dolzhenko, N. Kolotova

Heterocycles

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6

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Abstract

(2-Oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)acetic acids (4a-c, 9a-c) were prepared from 2-aminopyridines by acylation with maleic or citraconic anhydrides and followed by Michael addition. Formation of 3-methyl substituted derivatives (9a-c) from citraconic anhydride was found to be regioselective. The molecular conformations of the products in the solution and in the crystal form were discussed based on 1 H NMR spectral and X-Ray data.

Study Snapshot

This study demonstrates the regioselective synthesis of (2-Oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)acetic acids from 2-aminopyridines using maleic or citraconic anhydrides and Michael addition, with

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Structural Studies of (2-Oxo-2,3-dihydroimidazo[1,2-a]-pyridin-3-yl)acetic Acids

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References

Citations

Synthesis of 2,3-Dihydro-1H-imidazo[1,2-a]pyridinium Systems by Halocyclization of 1-Alkenyl(propargyl)-2-aminopyridinium Halides

This study demonstrates the synthesis of 2,3-dihydro-1H-imidazo[1,2-a]pyridinium systems by halocyclization of 1-Alkenyl(propargyl)-2-aminopyridinium halides, with potential applications in organic synthesis

Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines

This study developed practical and scalable procedures for preparing Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines, avoiding column chromatography in all synthetic steps.

Synthesis of N-(3-Arylmethyl-2-oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)benzamides

This study demonstrates a convenient method for synthesizing imidazo[1,2-a]pyridin-2-one derivatives using microwave irradiation in ethylene glycol, making it a promising strategy for drug discovery.

Synthesis and biological activity of substituted amides and hydrazides of 1,4-dicarboxylic acids (a review)

Substituted amides and hydrazides of 1,4-dicarboxylic acids show potential as biologically active compounds, with potential applications in various fields, such as medicine and agriculture.