Synthesis and Structure Determination of 1-(4-Methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide

doi:10.3390/m1374

Paper

Synthesis and Structure Determination of 1-(4-Methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide

Published May 31, 2022 · B. Kariuki, Bakr F. Abdel-Wahab, Abdelbasset A. Farahat

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Abstract

A reaction of equimolar equivalents of 1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1) and indoline-2,3-dione (2) in boiling ethanol for 4 h under acidic conditions gave 1-(4-methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide (3) in 88% yield. The structure of 3 was ascertained by NMR spectroscopy and single-crystal X-ray diffraction.

Study Snapshot

This study demonstrates the successful synthesis and structural determination of 1-(4-methoxyphenyl)-5-methyl-N'-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide (3), a novel tri

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Structure Determination of 1-(4-Methoxyphenyl)-5-methyl-N’-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide

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References

General Method of Synthesis of 5-(Het)arylamino-1,2,3-triazoles via Buchwald–Hartwig Reaction of 5-Amino- or 5-Halo-1,2,3-triazoles

This study developed a novel method for synthesizing novel 5-(het)arylamino-1,2,3-triazole derivatives using the Buchwald-Hartwig reaction, with palladium complex [(THP-Dipp)Pd(cinn)Cl] as the most active

Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency

Isatin-derivatives show promising anticancer properties, with potential for further improvements through structural modifications, metalation, and drug delivery systems.

Isatin containing heterocycles for different biological activities: Analysis of structure activity relationship

Isatin-containing heterocycles show diverse biological activities, including anticancer, anti-inflammatory, and antiviral properties, and can be synthesized using various methods.

Isatin dimers and their biological activities

Isatin dimers show potential as promising drug candidates with enhanced activity, reduced toxicity, and improved pharmacological, pharmacokinetic, and physicochemical profiles.

Synthesis and Structure Elucidation of N′-(4-Methoxybenzylidene)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide

N′-(4-Methoxybenzylidene)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide (3) is a novel compound with potential applications in pharmaceuticals and nutraceuticals.

Citations

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Note 2-( ( 5-( 5-Methyl-2-phenyl-1 H-imidazol-4-yl )-1 , 3 , 4-oxadiazol-2-yl ) thio )-1-phenylethan-1-one

This study successfully synthesized 2-((5-(5-methyl-2-phenyl-1H-imidazol-4-yl)-1,3,4-oxadiazol-2-yl)thio)-1-phenylethan-1-one) in 76% yield, confirming its structure through single