Paper
Synthesis and structure elucidation of the condensation products between thiophene dicarbaldehydes and aromatic amines: potential analgesic and anti-inflammatory agents
Published Sep 1, 1988 · F. Benachenhou, M. Mesli, M. E. Borai
Journal of Heterocyclic Chemistry
13
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Abstract
Thiophene-3,4-dicarbaldehyde 1 reacts in the presence of 2-mercaptoethanol to yield N-aryl-5,6-dihydro-4-oxo-4H-thieno [3,4-c] pyrroles 2 and N-aryl-4-arylimino-5,6-dihydro-4H-thieno [3,4-c] pyrroles 3, while thiophene 2,3-dicarbaldehyde 4 reacts with aromatic amines to give N-aryl-5,6-dihydro-6-oxo-4H-thieno [2,3-c] pyrroles 5 in good yields. Labelling experiments and nmr spectral analysis give evidences for the possible reaction mechanism
Thiophene dicarbaldehydes and aromatic amines can produce analgesic and anti-inflammatory compounds with potential therapeutic applications.
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